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1

Bioactivation of Drugs: Risk and Drug Design

Walsh, John S., Miwa, Gerald T.

Journal:

Annual Review of Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 2.25 MB

english, 2011

2

Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Xia, Cindy Q., Xiao, Guangqing, Liu, Ning, Pimprale, Satish, Fox, Lisa, Patten, Chris J., Crespi, Charles L., Miwa, Gerald, Gan, Liang-Shang

Journal:

Molecular Pharmaceutics

Année:

2006

Langue:

english

Fichier:

PDF, 245 KB

english, 2006

3

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

Bjornsson, Thorir D., Callaghan, John T., Einolf, Heidi J., Fischer, Volker, Gan, Lawrence, Grimm, Scott, Kao, John, King, S. Peter, Miwa, Gerald, Ni, Lan, Kumar, Gondi, McLeod, James, Obach, Scott R.

Journal:

Journal of Clinical Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 192 KB

english, 2003

4

Strategy of Utilizing In Vitro and In Vivo ADME Tools for Lead Optimization and Drug Candidate Selection

Balani, Suresh, Miwa, Gerald, Gan, Liang-Shang, Wu, Jing-Tao, Lee, Frank

Journal:

Current Topics in Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 89 KB

english, 2005

5

Kinetic isotope effects and ‘metabolic switching’ in cytochrome P450-catalyzed reactions

Gerald T. Miwa, Anthony Y. H. Lu

Journal:

Année:

1987

Langue:

english

Fichier:

PDF, 633 KB

english, 1987

6

The synthesis of 14C, 3H and 2H labeled 7-ethoxycoumarins

John S. Walsh, Holly E. Mertel, Gerald T. Miwa

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1983

Langue:

english

Fichier:

PDF, 266 KB

english, 1983

7

Determination of drug plasma protein binding by solid phase microextraction

Florin Marcel Musteata, Janusz Pawliszyn, Mark G. Qian, Jing-Tao Wu, Gerald T. Miwa

Journal:

Journal of Pharmaceutical Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 188 KB

english, 2006

8

Application of quantitative GC-mass spectrometry to study of pharmacokinetics of amphetamine and phentermine

Arthur K. Cho, Barbara J. Hodshon, Björn Lindeke, Gerald T. Miwa

Journal:

Journal of Pharmaceutical Sciences

Année:

1973

Langue:

english

Fichier:

PDF, 416 KB

english, 1973

9

Elucidation of potential bortezomib response markers in mutliple myeloma patients

Frank Y. Hsieh, Elizabeth Tengstrand, Teresa M. Pekol, Roberto Guerciolini, Gerald Miwa

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2009

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2009

10

Toxicological Protein Biomarker Analysis—An Investigative One-week Single Dose Intravenous Infusion Toxicity and Toxicokinetic Study in Cynomolgus Monkeys using an Antibody–cytotoxic Conjugate against Ovarian Cancer

Frank Y. Hsieh, Elizabeth Tengstrand, Lily Y. Li, Yuling N. Huang, Mark N. Milton, Lee Silverman, Carl Alden, Gerald Miwa, Frank Lee

Journal:

Pharmaceutical Research

Année:

2008

Langue:

english

Fichier:

PDF, 901 KB

english, 2008

11

Drug residue formation from ronidazole, a 5-nitroimidazole. VII. Comparison of protein-bound products formed in vitro and in vivo

Gerald T. Miwa, Raul F. Alvaro, John S. Walsh, Regina Wang, Anthony Y.H. Lu

Journal:

Chemico-Biological Interactions

Année:

1984

Langue:

english

Fichier:

PDF, 781 KB

english, 1984

12

Drug residue formation from ronidazole, a 5-nitroimidazole. VIII. Identification of the 2-methylene position as a site of protein alkylation

Raul F. Alvaro, Peter G. Wislocki, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Chemico-Biological Interactions

Année:

1992

Langue:

english

Fichier:

PDF, 533 KB

english, 1992

13

Studies with nitrogen-containing steroids and freshly isolated rat hepatocytes: Role of cytochrome P-450 in detoxication

Gregory L. Kedderis, Lois S. Argenbright, Gerald T. Miwa

Journal:

Toxicology and Applied Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 870 KB

english, 1988

14

The role of metabolism and covalent binding in the cytotoxicity of a nitrogen-containing steroid toward rat hepatocytes

Gregory L. Kedderis, Lois S. Argenbright, Gerald T. Miwa

Journal:

Toxicology and Applied Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 518 KB

english, 1990

15

Drug safety evaluation through biomarker analysis—A toxicity study in the cynomolgus monkey using an antibody-cytotoxic conjugate against ovarian cancer

Frank Y. Hsieh, Elizabeth Tengstrand, Ju-Whei Lee, Lily Y. Li, Lee Silverman, Bill Riordan, Gerald Miwa, Mark Milton, Carl Alden, Frank Lee

Journal:

Toxicology and Applied Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 601 KB

english, 2007

16

Aldrin Epoxidation Catalyzed by Purified Rat-Liver Cytochromes P-450 and P-448 High Selectivity for Cytochrome P-450

Thomas WOLFF, Helmut GREIM, Mou-Tuan HUANG, Gerald T. MIWA, Anthony Y. H. LU

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 617 KB

english, 1980

17

The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450

Gerald T. Miwa, Wayne Levin, Paul E. Thomas, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Année:

1978

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1978

18

A simple and rapid procedure for the purification of phenobarbitalinducible cytochrome P-450 from rat liver microsomes

Susan B. West, Mou-Tuan Huang, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Année:

1979

Langue:

english

Fichier:

PDF, 2.34 MB

english, 1979

19

Selective inactivation of cytochrome P-450 isozymes by suicide substrates

Paul R.Ortiz De Montellano, Bruce A. Mico, James M. Mathews, Kent L. Kunze, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Année:

1981

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1981

20

Studies on the stimulation of cytochrome P-450-dependent monooxygenase activity by dilauroylphosphatidylcholine

Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Année:

1981

Langue:

english

Fichier:

PDF, 475 KB

english, 1981

21

The association of cytochrome P-450 and NADPH-cytochrome P-450 reductase in phospholipid membranes

Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Année:

1984

Langue:

english

Fichier:

PDF, 541 KB

english, 1984

22

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: Full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters

Gerald T. Miwa, Nobuhiro Harada, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Année:

1985

Langue:

english

Fichier:

PDF, 679 KB

english, 1985

23

Mechanism of reductive activation of a 5-nitroimidazole by flavoproteins: Model studies with dithionite

Gregory L. Kedderis, Lois S. Argenbright, Gerald T. Miwa

Journal:

Archives of Biochemistry and Biophysics

Année:

1988

Langue:

english

Fichier:

PDF, 761 KB

english, 1988

24

The mechanism of the cytochrome P-448 mediated 6-hydroxylation of 7-ethoxycoumarin

John S. Walsh, Gerald T. Miwa

Journal:

Biochemical and Biophysical Research Communications

Année:

1984

Langue:

english

Fichier:

PDF, 295 KB

english, 1984

25

The metabolic activation of ronidazole [(1-methyl-5-nitroimidazole-2-yl)-methyl carbamate] to reactive metabolites by mammalian, cecal bacterial and T. foetus enzymes

Gerald T. Miwa, Regina Wang, Raul Alvaro, John S. Walsh, Anthony Y.H. Lu

Journal:

Biochemical Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 504 KB

english, 1986

26

In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450

Regina W. Wang, Gerald T. Miwa, Lois S. Argenbright, Anthony Y.H. Lu

Journal:

Biochemical Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 401 KB

english, 1988

27

Induction of rat liver cytosol methyl red azo-reductase by 3-methylcholanthrene assayed by a sensitive fluorometric method

Mou-Tuan Huang, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Biochemical and Biophysical Research Communications

Année:

1978

Langue:

english

Fichier:

PDF, 373 KB

english, 1978

28

Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats

Arthur I. Cederbaum, Gerald Miwa, Gerald Cohen, Anthony Y.H. Lu

Journal:

Biochemical and Biophysical Research Communications

Année:

1979

Langue:

english

Fichier:

PDF, 402 KB

english, 1979

29

Stimulation of microsomal N-demethylation by solubilized NADPH-cytochrome c reductase

Gerald T. Miwa, Arthur K. Cho

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 294 KB

english, 1976

30

Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles

Walsh, John S., Wang, Regina, Bagan, Edward, Wang, C. C., Wislocki, Peter, Miwa, Gerald T.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1987

31

[Part 1: Biological Sciences] || N-acetyl-p-benzoquinone Imine: A Cytochrome P-450-Mediated Oxidation Product of Acetaminophen

David C. Dahlin, Gerald T. Miwa, Anthony Y. H. Lu and Sidney D. Nelson

Journal:

Proceedings of the National Academy of Sciences

Année:

1984

Langue:

english

Fichier:

PDF, 848 KB

english, 1984

32

Role of superoxide in the N-oxidation of N-(2-methyl-1-phenyl-2-propyl)hydroxylamine by the rat liver cytochrome P-450 system

Duncan, John D., Di Stefano, Emma W., Miwa, Gerald T., Cho, Arthur K.

Journal:

Année:

1985

Langue:

english

Fichier:

PDF, 922 KB

english, 1985

33

Species-Specific, P450- and Sulfotransferase-Mediated Novel Ring Contraction of a Naphthyridine- N -Oxide Compound in Cynomolgus Monkey †

Daniels, J. Scott, Espina, Robert, Cao, Kevin, Yuan, Haodan, Lin, Jianrong, Diamond, Sharon, Johnson, Barry, Rodgers, James, Prakash, Shimoga, Unger, Steve, Christ, David, Miwa, Gerald, Gan, Liang-Sha

Journal:

Chemical Research in Toxicology

Année:

2007

Langue:

english

Fichier:

PDF, 196 KB

english, 2007

34

Oxidative Deboronation of the Peptide Boronic Acid Proteasome Inhibitor Bortezomib: Contributions from Reactive Oxygen Species in This Novel Cytochrome P450 Reaction

Labutti, Jason, Parsons, Ian, Huang, Ron, Miwa, Gerald, Gan, Liang-Shang, Daniels, J. Scott

Journal:

Chemical Research in Toxicology

Année:

2006

Langue:

english

Fichier:

PDF, 390 KB

english, 2006

35

Covalent interaction of 5-nitroimidazoles with DNA and protein in vitro: mechanism of reductive activation

Kedderis, Gregory L., Argenbright, Lois S., Miwa, Gerald T.

Journal:

Chemical Research in Toxicology

Année:

1989

Langue:

english

Fichier:

PDF, 503 KB

english, 1989

36

The metabolic activation of nitroheterocyclic therapeutic agents

Kedderis, Gregory L., Miwa, Gerald T.

Journal:

Drug Metabolism Reviews

Année:

1988

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1988

37

Tissue Drug Residues and their Toxicological Significance

Lu, Anthony Y. H., Wislocki, Peter G., Chiu, Shuet-Hing Lee, Miwa, Gerald T.

Journal:

Drug Metabolism Reviews

Année:

1987

Langue:

english

Fichier:

PDF, 753 KB

english, 1987

38

Bis(monoacylglycerol)phosphate as a non-invasive biomarker to monitor the onset and time-course of phospholipidosis with drug-induced toxicities

Tengstrand, Elizabeth A, Miwa, Gerald T, Hsieh, Frank Y

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2010

Langue:

english

Fichier:

PDF, 616 KB

english, 2010

39

Mechanism of metabolic activation of ronidazole, a 5-nitroimidazole

LU, ANTHONY Y. H., WISLOCKI, PETER G., BAGAN, EDWARD S., WANG, REGINA W., WALSH, JOHN S., MIWA, GERALD T.

Journal:

Biochemical Society Transactions

Année:

1984

Langue:

english

Fichier:

PDF, 343 KB

english, 1984

40

[Annual Reports in Medicinal Chemistry] Volume 13 || Chapter 22. Molecular Aspects of Drug Metabolism

Miwa, Gerald T.

Année:

1978

Langue:

english

Fichier:

PDF, 871 KB

english, 1978

41

Microsomes, Drug Oxidations and Chemical Carcinogenesis || KINETIC ISOTOPE EFFECTS IN CYTOCHROME P-450-CATALYZED OXIDATION REACTIONS. I. SUBSTRATE - CYTOCHROME P-450 INTERACTIONS

Miwa, Gerald T.

Année:

1980

Langue:

english

Fichier:

PDF, 261 KB

english, 1980

42

Microsomes, Drug Oxidations and Chemical Carcinogenesis || KINETIC ISOTOPE EFFECTS IN CYTOCHROME P-450-CATALYZED OXIDATION REACTIONS. I. SUBSTRATE - CYTOCHROME P-450 INTERACTIONS

Miwa, Gerald T.

Année:

1980

Fichier:

PDF, 261 KB

1980